The OncoMouse or Harvard mouse is a type of laboratory mouse (Mus musculus) that has been genetically modified using modifications designed by Philip Leder and Timothy A Stewart [1] of Harvard University to carry a specific gene called an activated oncogene (v-Ha-ras under the control of the mouse mammary tumor virus promoter).

That would be the Oncomouse, an animal that made scientific and legal history as the first transgenic mammal to be the subject of a United States patent.

Nov 16, 2018 · His name was OncoMouse. The mouse, genetically engineered to have a predisposition for cancer, allowed researchers to study the disease in an intact living organism. It promised to transform cancer research, but not everyone was happy.

In early 1983 Harvard University scientists Philip Leder and Timothy Stewart created OncoMice by using a fine glass needle to inject known cancer genes into mouse embryos just after fertilization. This genetic modification not only made the mice prone to cancer, but also ensured that they would pass the cancer genes to their offspring.

Genetically engineered mouse models (GEMMs) have contributed significantly to the field of cancer research. In contrast to cancer cell inoculation models, GEMMs develop de novo tumors in a natural immune‐proficient microenvironment.

In this historical reflection, we focus on the concurrent development of the first transgenic mice carrying dominant oncogenes, termed “oncomice,” involving four independent research groups who were largely unaware of each other’s strategies, efforts, and progress.

Jun 17, 2020 · OncoMouse is what scientists call a “mouse model”—special strain of mice used to study a particular human disease or condition. Mouse models are the foremost research tool for studying human disease and human health.

OncoMouse was created in 1984 by replacement of the normal mouse myc gene, which is believed to regulate expression of 15% of all genes by acting as a transcription factor, with a virus tumor promoter/myc fusion recombinant gene. The …

Jun 22, 1984 · Oncomouse was created in 1984 by replacement of the normal mouse myc gene with a virus tumor promoter/ myc fusion recombinant gene. The mice and their offspring developed carcinomas. This first mouse was created at …

The OncoMouse or Harvard mouse is a type of laboratory mouse (Mus musculus) that has been genetically modified using modifications designed by Philip Leder and Timothy A Stewart of Harvard University to carry a specific gene called an activated oncogene (v-Ha-ras under the control of the mouse mammary tumor virus promoter).