eLife20h
Scale matters: Large language models with billions (rather than millions) of parameters better match neural representations of natural language
Recent research has used large language models (LLMs) to study the neural basis of naturalistic language processing in the human brain. LLMs have rapidly grown in complexity, leading to improved ...
eLife20h
Membrane potential modulates ERK activity and cell proliferation
Department of Physiology, Division of Life Science, Faculty of Medicine, Osaka Medical and Pharmaceutical University, Takatsuki, Japan ...
eLife13h
Study highlights complexity of menopausal hormone therapy’s impact on brain health
A large UK study finds that the effects of menopausal hormone therapy on female brain health might vary depending on the duration of use and history of gynaecological surgery.
eLife21h
Publishing with eLife: “authors have a lot of control in the publication process”
What do authors think about publishing in eLife’s model? We spoke with Meike van der Heijden to find out about her experience.
eLife1d
Aberration correction in long GRIN lens-based microendoscopes for extended field-of-view two-photon imaging in deep brain regions
Two-photon (2P) fluorescence imaging through gradient index (GRIN) lens-based endoscopes is fundamental to investigate the functional properties of neural populations in deep brain circuits. However, ...
eLife1d
Subtypes and proliferation patterns of small intestine neuroendocrine tumors revealed by single cell RNA sequencing
Endocrine Neoplasia Translational Research Center, Division of Endocrinology, Diabetes and Metabolism, Chaim Sheba Medical Center, and Tel Aviv University Faculty of Medicine, Ramat Gan, Israel This ...
eLife1d
Nociceptor Neurons Control Pollution-Mediated Neutrophilic Asthma
The study is a valuable addition to the field, showing how particulate matter may be acting via nociceptor neurons towards neutrophilic asthma exacerbations. The solid evidence for the role of a ...
eLife2d
Decisions: Tracking the evolution of a single choice
Measuring the activity of hundreds of neurons in macaque brains simultaneously provides further evidence that drift-diffusion dynamics underlie how decisions are made in the brain.
eLife1d
Distinct trafficking routes of polarized and non-polarized membrane cargoes in Aspergillus nidulans
Membrane proteins are sorted to the plasma membrane (PM) via Golgi-dependent trafficking. However, our recent studies challenged the essentiality of Golgi in the biogenesis of specific transporters.
eLife4d
Xist RNA binds select autosomal genes and depends on Repeat B to regulate their expression
This valuable study addresses potential roles of the master regulator of X chromosome inactivation, the Xist long non-coding RNA, in autosomal gene regulation. Using data from mouse cells, the authors ...
eLife6d
Rabphilin-3A negatively regulates neuropeptide release, through its SNAP25 interaction
Live imaging at single-vesicle resolution reveals rabphilin-3A as the first identified negative regulator of neuropeptide release in mammalian neurons.
eLife8d
A host enzyme reduces non-alcoholic fatty liver disease by inactivating intestinal lipopolysaccharide
The findings are significant for the liver research community and others interested in the gut-liver axis. (A) AOAH cleaves the two piggyback fatty acyl chains from the lipid A moiety, inactivating ...