During a recent appearance on “The Howard Stern Show," the comedian, 43, opened up about her scary experience trying the medication for weight-loss purposes.

Amy explained that she "tried" Ozempic three years ago, and that her experience may be tied to her possession of the GDF15 gene, which makes carriers "extremely prone" to nausea. "I was, like, bedridden,

Amy Schumer has openly shared details of her Ozempic use in the past, as well as slamming celebrities who keep their own weight-loss drug regimens hidden in the shadows.But the actress also made it clear that she stopped taking it soon after she started — and now,

Amy Schumer lost 30 pounds using Ozempic, but experienced negative side effects. She was "bedridden" and didn't have energy. Amy has a gene that makes her "extremely prone to nausea," which she believes is why she experienced extreme vomiting.