“The Substance” follows an Oscar-winning actress (Moore) who loses her job as the host of a popular daytime aerobics workout TV show upon hitting 50. After she takes a black-market drug, she creates a younger, better version of herself (Margaret Qualley) — but with dire consequences.

The Substance has been entered into the comedy/musical category for this year’s Golden Globes. French filmmaker Coralie Fargeat’s dark-humored film about an aging movie star, played by Demi Moore, is so extreme it has prompted mass cinema walkouts around the world.