RNA-induced silencing complex (RISC): A complex involved in RNA interference that regulates gene expression by degrading target mRNAs or inhibiting their translation. Apoptosis: A form of ...

View Full Profile. Learn about our Editorial Policies. The natural RNAi mechanism can be directed by either short interfering RNA (siRNA) or microRNA (miRNA). 1 There are four key steps in the RNAi ...

When performing RNA interference (RNAi ... The siRNA associates with cellular proteins to form the RNA-induced silencing complex (RISC). The siRNA antisense strand guides RISC to the target ...

RNA interference is a conserved biological response to double ... within the RNA-induced silencing complex (RISC). We have written a review with John van der Oost (Wangeningen University) and Eugene ...

RNA interference, or RNAi, is all the rage these days. According to the Web of Science database (ISI, Philadelphia), the number of articles on the topic jumped from nine in 1998 to 229 in 2002. Why ...

In 1998, Andrew Fire and Craig Mello published a groundbreaking study demonstrating that double-stranded RNA (dsRNA) could silence genes in the nematode Caenorhabditis elegans. This discovery laid the ...