Nature5y
Gene targeting with recombinant adenoviral vectors
A nonfunctional mutant of a reporter gene (W in the figure) is introduced or is present in a cell (a). In the recombinant targeting vector (b), the viral genes are replaced by a sequence that is ...
Nature1y
Vagaries of conditional gene targeting
Conditional gene targeting based on excision or inversion of loxP-flanked DNA segments by Cre recombinase is a powerful technology for the analysis of gene function, but unexpected expression ...
News Medical on MSN10d
New grant funds first-of-its-kind gene therapy to treat aggressive brain cancer
The California Institute for Regenerative Medicine has awarded a $6 million grant to USC investigators pioneering a new first-of-its-kind genetic therapy for glioblastoma, a severe form of brain ...
GEN11d
Optimizing AAV Gene Delivery: Hitting the Target Safely and Effectively
Researchers are enhancing the best features of AAV capsids and overcoming their limitations to accelerate gene-based therapies.
Hosted on MSN9d
USC receives grant for gene therapy targeting glioblastoma
The University of Southern California (USC) has received a $6m grant from the California Institute for Regenerative Medicine ...
Mutations in two gene pairs point to a promising drug target in 5% of adult cancers
Scientists from the Cancer Dependency Map (DepMap) at the Broad Institute of MIT and Harvard and Columbia University have ...